Cincinnati 6, Washington 1
Hunter Greene struck out 12 in six innings and Tyler Stephenson went 2-for-3 with two RBIs in his season debut as the Cincinnati Reds defeated the visiting Washington Nationals 6-1 on Friday.
San Diego 9, Pittsburgh 4
Luis Arraez had three run-scoring hits to lead the San Diego Padres to a 9-4 win over the host Pittsburgh Pirates on Friday night in the opener of a three-game series.
Philadelphia 3, Arizona 2
Kyle Schwarber and Max Kepler hit seventh-inning home runs as the Philadelphia Phillies rallied past the visiting Arizona Diamondbacks 3-2 on Friday.
Baltimore 3, Kansas City 0
Baltimore's Dean Kremer threw seven shutout innings and Ryan O'Hearn broke up a scoreless tie with a two-run, seventh-inning home run as the Orioles beat the visiting Kansas City Royals 3-0 in the opener of a three-game series Friday night.
NY Yankees 3, Tampa Bay 0
Paul Goldschmidt hit a three-run homer in the fifth inning, Max Fried allowed one hit in seven sparkling innings and the New York Yankees earned a 3-0 victory over the visiting Tampa Bay Rays on Friday night.
Toronto 5, Cleveland 3
Nathan Lukes hit a two-run, go-ahead single with two outs in the eighth inning and the Toronto Blue Jays defeated the visiting Cleveland Guardians 5-3 on Friday night.
Boston 6, Minnesota 1
Rafael Devers hit a key two-run single in the seventh inning as the Boston Red Sox rallied for five late runs to beat the visiting Minnesota Twins 6-1 in the opener of a three-game series Friday night.
Athletics 6, Miami 1
Gunnar Hoglund gave up one run over six innings in his major league debut and JJ Bleday homered, doubled and scored three runs as the visiting Athletics won their third straight game, 6-1, over the Miami Marlins in the opener of a three-game series on Friday night.
LA Dodgers 2, Atlanta 1
Yoshinobu Yamamoto threw six scoreless innings and Mookie Betts hit the decisive home run to lead the visiting Los Angeles Dodgers to a 2-1 win over the Atlanta Braves on Friday in the opener of their three-game series.
Chi. White Sox 7, Houston 3
Edgar Quero had two hits and two RBIs and Luis Robert Jr. homered to back six strong innings from Jonathan Cannon as the host Chicago White Sox defeated the Houston Astros 7-3 on Friday in the opener of a three-game set.
Seattle 13, Texas 1
Cal Raleigh hit a solo home run and a grand slam while Bryan Woo and two relievers combined on a three-hitter as the Seattle Mariners routed the Texas Rangers 13-1 on Friday in the opener of a three-game series at Arlington, Texas.
Chi. Cubs 10, Milwaukee 0
Michael Busch hit a grand slam and Pete Crow-Armstrong launched two solo home runs on Friday, helping guide the visiting Chicago Cubs to a 10-0 victory over the Milwaukee Brewers on Friday.
NY Mets 9, St. Louis 3
Pete Alonso and Brandon Nimmo used the long ball to power the visiting New York Mets to a 9-3 victory Friday over the St. Louis Cardinals and snap a two-game losing streak as well.
Detroit 9, LA Angels 1
Riley Greene homered twice during an eight-run ninth inning to lift the Detroit Tigers to a 9-1 victory over the Los Angeles Angels on Friday night in Anaheim, Calif.
San Francisco 4, Colorado 0
Robbie Ray allowed just two singles in seven shutout innings, LaMonte Wade Jr. hit an RBI double in a three-run second inning and the San Francisco Giants blanked the visiting Colorado Rockies 4-0 on Friday night.